Vitamin E is a fat-soluble vitamin that has antioxidant properties. It is present in vegetable oils (safflower, sunflower, corn, soybean), nuts (almonds, peanuts, hazelnuts), sunflower seeds, and green leafy vegetables (spinach, broccoli). A balanced diet provides all the vitamin E you need, but many people take supplements of the vitamin on the assumption that if a little is good, more is better. Is it really so? Let’s examine the evidence.


The health claims of vitamin E

Vitamin E has been claimed to protect against heart disease, certain cancers, dementia, skin aging and scar formation. None of these claims has the evidence to support it. The vitamin does have a role in red blood cell formation and in vitamin K synthesis, which is important in blood clotting, but the amount needed for these functions is found in a well-balanced diet. So what’s the basis for all the other claims?


Chemical vs. biological antioxidant activity

The chemical name of vitamin E is tocopherol, and it is present in two forms (isomers): alpha-tocophrol and gamma-tocopherol. The supplements are usually made up of the alpha-tocopherol isomer, but both forms are antioxidants. Many studies have shown that oxygen radicals are part of the inflammatory process and are injurious to tissues. Hence the conclusion that vitamin E, being an antioxidant, must be “good for you”. The problem is that the antioxidant effect is not the only biological activity of the vitamin. And, in fact, several studies failed to show a biological effect of the vitamin, its chemical antioxidant activity notwithstanding.


Effect on bones

Bones are metabolically very active organs: they are being constantly resorbed by cells called osteoclasts and built up by cells called osteoblasts. The balance between the two is crucial: if the activity of osteoclasts (the Yin half of the famous twins) is not balanced by the osteoblasts (the Yang half), osteoporosis is the all too familiar result.

Postmenopausal women lose the anti-inflammatory protection of estrogen, causing an accelerated resorption of bone. Under normal circumstances, the osteoblasts would spring into action and work overtime to right the imbalance. And it is the gamma-tocopherol that apparently prods the osteoblasts into action. In the Journal of Bone and Mineral Research, Maryam Hamidi and her colleagues showed that women who took vitamin E, comprised of alpha-tocopherol, suppressed their levels of gamma-tocopherol, with the result that the natural balance between bone formation and bone resorption was disrupted, leading to loss of bone tissue.

Fujita and his colleagues (Nature Medicine) showed in mice what is happening. Alpha tocopherol, the synthetic form of vitamin E supplements, stimulates the formation of osteoclasts from precurser cells, and suppresses gamma-tocopherol, thus tilting the balance toward bone reosorption.

In summary: the first study showed suppression of gamma-tocopherol by alpha-tocopherol, the form we take as a vitamin E supplement. The second study, albeit in mice, showed in great molecular detail how alpha tocopherol enables the formation of osteoclasts, the destroyers of bone tissue.

There are two lessons here. First, we assumed that vitamin E exerts its influence by virtue of being an antioxidant. It is now evident that it has other effects, like stimulation of osteoclasts, that have nothing to do with antioxidant activity. Second, based on skimpy evidence we rushed to conclusions that were later shown to be inaccurate at best. In biology and medicine, conclusions based on “it makes sense” are simply not good enough. Biology is infinitely more complex than our powers of reasoning. We need to be a bit more humble.


So, what should we do?

My first preference would be to recommend having a diet rich in vegatables and other good sources of vitamin E. If you feel that you absolutely need supplementation, using multivitamins, then stick to the recommended daily allowance (RDA) of 15 mg (or 22.4 International Units) a day. And by all means avoid the mega-doses of vitamin E pills.

Dov Michaeli, MD, PhD
Dov Michaeli, MD, PhD loves to write about the brain and human behavior as well as translate complicated basic science concepts into entertainment for the rest of us. He was a professor at the University of California San Francisco before leaving to enter the world of biotech. He served as the Chief Medical Officer of biotech companies, including Aphton Corporation. He also founded and served as the CEO of Madah Medica, an early stage biotech company developing products to improve post-surgical pain control. He is now retired and enjoys working out, following the stock market, travelling the world, and, of course, writing for TDWI.


  1. Agree with Al, Vitamin D is having its Golden Age right now. Eventually, we will better understand its role-who really needs replacement therapy. As someone who was profoundly, measurably Vit D deficient (after a week in the sun in Costa Rica), I had more confident that it was a real deficiency when it was corrected by a Vit D load, followed by daily D.

  2. It seems like just about every claim for health benefits of megadoses of some-or-another nutrient eventually get debunked by experimentation, meta-analysis or natural experiments on whole populations.

    I suspect Vitamin D is next on the list — its claims seem too good to be true.


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