is massage good for you
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Massage therapy feels good and everybody loves it. But is it also good for your health? Intuitively we “know” that it is “good for you”, but where is the objective evidence?

Weekend warrior syndrome

For the weekend warriors, which is most of us, the feeling is familiar. You run 10 miles or do one hundred pushups. Immediately afterward, you feel great and disgustingly self-righteous.

But then comes the morning after and it’s payback time. Your muscles are sore and you are waddling like a duck. What’s more, you feel pretty stupid for overdoing it.

The first thing you might want to do is reach for the ibuprofen or some other non-steroidal anti-inflammatory drug (NSAID). Don’t! There is a better way to deal with your symptoms.

The experiment

A 2012 paper in Science Transnational Medicine by Mark A. Tarnopolsky and his colleagues from McMaster University Ontario, is the first study that puts our intuitive “gut feeling” about the benefits of massage on solid experimental ground. The paper was also featured in an article in the New York Times. 

To assess the effects of massage, they administered either massage therapy or no treatment to separate quadriceps of 11 young male participants after exercise-induced muscle damage. They “inflicted” the damage by having the volunteers exercise on a stationary bicycle for over an hour to exhaustion.

Muscle biopsies were acquired from the quadriceps (vastus lateralis). On a first visit, they biopsied one leg of each subject at rest. At a second session, after the exercise on the stationary bicycle, they massaged one thigh of each subject for 10 minutes, leaving the other to recover on its own. I

Immediately after the massage, they biopsied the thigh muscle in each leg again. After allowing another 2.5 hours of rest, they did a second biopsy to track the process of muscle injury and repair.

The results

They found the kneading, pushing and pressing of the muscle during massage activated two intracellular signaling cascades. One that responds to mechanical stimulation (FAK) and one that responds to extracellular chemical signals (ERK).

But wait, that’s not all. By examining the biopsies they found an increase in the biogenesis of new mitochondria. These are the tiny organelles in the cytoplasm that are the cell’s powerhouses.

How could cells increase its content of mitochondria in response to massage? By receiving a signal from a protein (PCG-1α) that triggers the synthetic mechanism of mitochondrial biogenesis. This protein was elevated in the massaged tissue.

Explaining what happened

These findings make perfect sense. After vigorous exercise, there are tiny tears in the muscles that need to be repaired. This explains the rise in cell growth and division signals, like FAK and ERK. Further, the intensive cellular activity that takes place during wound healing requires a lot of extra energy. This is supplied by the newly-formed mitochondria.

These findings explain the enhanced healing of the muscle. But there is another aspect to exercise-induced trauma. That is the injury itself. It turns out that massage of the injured muscle also helped reduce damage to the muscle fibers. When tissue is injured the body responds with inflammation.

Inflammation is a double-edged sword. It serves to clean out the cell debris caused by the trauma. However, in the process, it causes damage to the innocent bystanders who happen to reside in the neighborhood. To use military parlance, this is “collateral damage”.

Only when the inflammation subsides does the re-building of new tissue begin. The instigators of inflammation are the injured cells themselves, as well as white blood cells that rush to the injured site.

They secrete proteins called cytokines with such colorful names as interleukin 6 (IL 6) and  tumor necrosis factor-α (TNF-α). They also release intracellular factors such as heat-shock protein 27 (HSP27) and Nuclear Factor κB (NFκB).  All of these are signals for initiating and sustaining inflammation.

The effect of massage on the mediators of inflammation

Is there an effect of massage on the mediators of inflammation? Yes. It reduces their release, thereby limiting their injurious effect on the surrounding muscle fibers.

So now we have the complete picture of what we can call the cell biology of massage. It limits inflammation and its destructive activity. It also promotes rapid healing of the injured tissue.

Why not take drugs instead?

One last question. Why not simply take anti-inflammatory drugs? There are two reasons. First, they can interfere with wound healing and actually delay your return to full activity. Second, they are not as pleasant and emotionally healing as a massage given by a masseur or masseuse who knows what they are doing.

This, of course, assumes that massage has an effect of the brain, and it does. More on that in the next post.

Dov Michaeli, MD, PhD
Dov Michaeli, MD, PhD loves to write about the brain and human behavior as well as translate complicated basic science concepts into entertainment for the rest of us. He was a professor at the University of California San Francisco before leaving to enter the world of biotech. He served as the Chief Medical Officer of biotech companies, including Aphton Corporation. He also founded and served as the CEO of Madah Medica, an early stage biotech company developing products to improve post-surgical pain control. He is now retired and enjoys working out, following the stock market, travelling the world, and, of course, writing for TDWI.


  1. Good blog doc! I’m a licensed massage therapist for over 13 + years! I wholeheartedly ageee with You! Massages definitely help people ! I personally have witnessed MANY clients relieved from chronic pain and stress after a massage! I have always had great results with massages in my clients ! 😁❤

  2. […] Massages are often considered luxuries or unnecessary time sinks, even by managers and executives who can afford to visit a spa regularly.  You might think massages take up valuable time, they aren’t worth the price, or they’re just another kind of alternative medicine that doesn’t do a thing.  However, there’s a lot a massage can do for you if you visit an expert masseuse regularly, and these results are backed up by scientific evidence.  […]


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