lecithin supplements dangerous

Lecithin supplements have been heavily promoted as a panacea for:

  • Cardiovascular health
  • Liver and cell function
  • Fat transport and fat metabolism
  • Reproduction and child development
  • Physical performance and muscle function
  • Cell communication
  • Improvement in memory, learning, and reaction time
  • Relief of arthritis
  • Healthy hair and skin
  • Treatment for gallstones

I have always been suspicious of promotions that promise to cure all human ailments. But recently, I came across a paper that prompted me to examine the evidence behind those claims. I’ll save you an excruciatingly detailed account—none of the claims have any credible evidence to back it up. There is one possible exception. Lecithin is a natural emulsifier, so claims that it dissolves gallstones may be credible, except that I haven’t come across a good study documenting it. WebMD gives lecithin treatment of gallstones an unenthusiastic “recommendation” of possibly ineffective.

 

What is lecithin?

Chemically, lecithin is called phosphatidylcholine. It is found in egg yolk, meats, soy, and vegetables. Most commercial lecithin is made from soy. So, you’d assume that when you take lecithin supplements, you get phosphatidylcholine. In fact, as is the case with many nutritional supplements, commercial preparations vary widely (between 20% to 90%) in the amount the substance is actually in their product.

Why such variability? Because the suppliers of supplements were exempted by Congress from adhering to any standards of manufacture, purity, or claims of benefits. How this came about is emblematic of our broken political system, but don’t get me going on this.

Anyway, if only a fraction of commercial lecithin is made up of the real thing—phosphatidylcholine—then what makes up the rest? The answer: fatty acids! Not exactly the stuff to help in weight reduction, cardiovascular health, or liver function. In fact, it may work against all those potentially wonderful benefits.

 

What’s the downside of lecithin supplements?

If they don’t cause any harm, why not give it the benefit of the doubt? A future study may prove its benefit.

In a paper in Nature, Wang et al. of the Cleveland Clinic studied the metabolic fate of lecithin. But first, by way of explanation, let me introduce a new term. We are all familiar with the concept of genomics, meaning the study of the genome, or the total genetic content and its effect on health and disease. Similarly, the total of chemicals, substrates, and metabolites in the body is called the metabolome, and the study of those substances in health and disease is called metabolomics. The advantage of such an all-inclusive approach is that it is unbiased.

The classical scientific approach is to study a specific gene or molecule, essentially ignoring everything else. This is akin to peeping through a keyhole; you see only what the hole allows you to see. On the other hand, studying the whole genome or the whole metabolome gives a complete picture of everything that is involved in the process being studied.

For instance, for many years, type 2 diabetes was thought to involve only one or two genes. Why? Because these were the only genes that “made sense” as targets for study. The advent of whole-genome studies demonstrated the involvement of dozens of genes in the disease, which was a complete surprise.

Back to the paper. Wang and his collaborators used the metabolomic approach to look for circulating small molecules associated with coronary heart disease. They screened blood from patients who had experienced a heart attack or stroke and compared the results with those from the blood of people who had not. They found major differences in choline, betaine, and trimethylamine (TMA). It turns out that these metabolites are produced from lecithin by gut bacteria and converted to trimethylamine-N-oxide (TMAO). This terminal metabolite, TMAO, is a known atherogenic (involved in atherosclerotic plaque formation).

Indeed, when the gut flora was wiped out with an antibiotic, none of the metabolites appeared in the blood. Could it be that the gut flora in people with cardiovascular disease is different in some way from that of healthy people? We don’t know, but we do know that the physiological state of a person can determine the gut flora. For instance, the gut flora of obese people is markedly different from that of the non-obese.

Based on this study alone, we still can’t tell if these lecithin metabolites are causative factors, or whether they are just markers of the disease. Correlative studies can show only correlations, not cause and effect.

 

Wait, wait, there’s more

Is lecithin the only culprit that produces TMAO? Red meat contains another triethylamine, similar to choline and lecithin, called L-Carnitine, which should be metabolized by the gut flora into MAO and then converted to TMAO in the circulation. So the same Cleveland Clinic group examined the production of TMAO by omnivores, vegans, and vegetarians following ingestion of L-carnitine. Indeed, the omnivorous humans had higher levels of circulating TMAO. The reason? Meat eaters have gut bacterial flora different than vegetarians and vegans. It contains species that feast on triethylamines: choline, lecithin, and carnitine.

Now let’s look at an interesting study published in the prestigious New England Journal of Medicine by Tang and colleague. It was conducted in two phases. In the first phase, the investigators gave healthy participants a phosphatidylcholine challenge using a stable isotope–labeled form of the phospholipid. They then used mass spectrometry to monitor choline metabolites before and after the suppression of gut microbiota with broad-spectrum antibiotics.

They found that the phosphatidylcholine challenge increased all choline metabolites but that antibiotics suppressed the generation of TMAO, which reappeared when antibiotics were withdrawn. In the second phase, they examined the relationship between fasting plasma TMAO levels and incident cardiovascular events over a 3-year period in more than 4,000 participants undergoing elective coronary angiography. They found an independent, dose-dependent relationship between the metabolite and the risk of a cardiovascular event on the basis of the TMAO quartile: The highest quartile had 2.54 times the risk over the lowest quartile.

 

The bottom line

Here is what we know about lecithin:

  • The phospholipid phosphatidylcholine (lecithin) is the major dietary source of choline, a semi-essential nutrient that is part of the B-complex vitamin family. Choline has various metabolic roles, ranging from its essential involvement in lipid metabolism and cell-membrane structure to its role as a precursor for the synthesis of the neurotransmitter acetylcholine.
  • Red meat, processed meat, pork, and egg yolk contain high levels of lecithin.
  • Phosphatidylcholine (lecithin) is metabolized by gut flora into three metabolites that show up at high concentrations in people who have had a heart attack or a stroke. We metabolize those bacterial metabolites into TMAO, a known atherogenic.
  • A large 4,000-patient study over 3 years showed a significant correlation between TMAO levels and cardiac events and stroke.

Still, although highly suggestive, none of these studies have demonstrated a direct effect of lecithin, or its metabolite TMAO, as a cause of atherosclerosis.

 

So, how does one make a decision whether to take lecithin supplements?

Since the lecithin metabolite, TMAO, is a known atherogenic, I believe that until we better understand whether it actually causes atherosclerosis, the prudent approach would call for moderation and limiting your intake of these foodstuffs with high levels of lecithin. Further, since there is no credible evidence supporting claims of health benefits, there is no reason to take high doses of lecithin in the form of nutritional supplements. If you do choose to take them, you could be increasing your risk of a heart attack or stroke in exchange for no known benefit.


This post was initially published on 01/25/2012. It has been updated to include findings from the latest scientific studies.

Dov Michaeli, MD, PhD

Dov Michaeli, MD, PhD loves to write about the brain and human behavior as well as translate complicated basic science concepts into entertainment for the rest of us. He was a professor at the University of California San Francisco before leaving to enter the world of biotech. He served as the Chief Medical Officer of biotech companies, including Aphton Corporation. He also founded and served as the CEO of Madah Medica, an early stage biotech company developing products to improve post-surgical pain control. He is now retired and enjoys working out, following the stock market, travelling the world, and, of course, writing for TDWI.

139 COMMENTS

  1. Sorry Doc, but I must disagree with your statements about lecithin. High quality lecithin (like a leading brand that is non-GMO and contains 95% phosphatides) is recommended by at least some leading cardiologists. My father was diagnosed with severe heart disease about 10 years ago. It was so bad that the doctors were shocked he had not had an MI already. They wanted to rush him into surgery, but he insisted on handling it in a more natural way.

    His cardiologist told him it would be an uphill battle, but my dad finally reversed his heart disease. Among the myriad supplements he was encouraged to take was 95% phosphatide lecithin – 2 Tbsp daily. He has been taking it for 10 years, and in conjunction with diet, exercise, and other supplements his blood work and disease markers regularly come back looking better than mine (38 years his junior!).

      • Its safer especially if you’re taking higher doses because it’s soy-free. Some conditions require high doses like 10-20 grams. I’ve taken it for around 3 months now and I’ve had no side affects. I take around 10g per day. Not gonna say what for it’s personal but please do own research because there’s many uses with different doses for each. Shop online its way cheaper. I got a good sale from piping rock.com and it had same nutritional facts as the NOW brand. There’s many good reasons to supplement with it and not many side affects.

    • Hi Ryan, I totally agree with you. I really don’t get it why some medical doctors poop on natural and holistic medicine? I guess we have to take our own health into our own hands, because if we rely on the conventional doctors and medications we are for a big disappointment. I don’t care what they say, I go with my own instinct, and do my own research after all if I don’t no body will.

      Bless you

  2. One study doth not a conclusion make.

    It is not accurate to herald *one* primary study showing a correlation which, the writer himself, said doesn’t necessarily show cause and effect as, well, possibly showing cause and effect. Just like vitamin E being discared as a potentially harmful heart supplement, but only involving studies on d-alpha tocopherol and not the constellation of vitamin E – alpha, beta, gamma, etc.. Put another way, instead of looking through the keyhole….

    I’ll keep taking my lecithin as I have for 20 years – my last 2 stress tests being perfect- until a preponderance of evidence tells me otherwise. I decided.

    • Indeed. In looking at all the comments on this phony article, it’s clear that people are not stupid and are not blind. And the author is on the side of the big pharma. Afterall the website title is ‘the doctor…’. Exactly the type of nonsense a doctor would write. Same type of doctor who is against vitamin C, orthomolecular medicine and write “Surgery, drug treatment and radiation remain the major treatment modalities” when we have several different treatments and cures for cancers which don’t resort to the cut, burn and poison barbaric ways. Shame on you dear ‘doctor’.

  3. I was diagnosed with gallbladder sludge and gastritis in August of 2012. For months i was seeing different gastroenterologists who encouraged me to consider having my gallbladder removed. For months they had me on PPI and actigall. None of which worked. Within 2 days of taking soy lecithin right before bed, my gallbladder pains virtually disappeared. It’s been about 2 weeks now (June 2013) and i have not felt this relieved since i started having those pains and attacks on my right side.

    • Thanks for contributing, Jay. The millions of negligent homicides by the medical industry exposes their singular motive of money being their God, with the “care of patients” not being able to be found on the list by me.

      That’s not to say that some doctors are exceptions. I knew there are exceptions, but a good honest doctor being an exception is a tragic testimony of the industry that killed both my parents.

    • Hi, can you tell me how much you were taking as I have gallstone too! I bought sunflower lecithin 1200 mg. but I don’t know how many to take a day. Can you please reply!

      • Best forum comments on it pointed to using up to 2-4 GRAMS of phosphatidylcholine per day (basically lots as much as needed), and GB-3 (from endomet labs) to get the bile moving.
        It softens the stones and lets them move out.

    • I too was diagnosed with gallstones in 2010. Since then I had 2 emergency trips to accident and emergency. The last in 2012. My doctor made me sign a disclaimer for refusing to have my gall bladder removed. My reason for refusal is that we have keloid skin in our family and even laparoscopic surgery would mean I would be left with at least 4 tumour style scars that would continue to grow and are painful. I researched on the internet about gallstones under conventional and natural remedies. Went in to health shops and asked. One natural remedy stood out. Soy Lecithin. And the health shop recommended it also. I bought the Mega Lecithin from Holland and Barratt 1360mg. Started taking it. After 2 weeks my gallbladder was no longer irritated, no pain or discomfort. It is now May 2017 and I have not had a Gall Bladder attack since 2012. I am not on Lecithin constantly. Once or twice a year I go on a course for a month and that’s it. Unfortunately, taking out the Gall Bladder does not necessarily solve the pain problem. Some people still have pain? Really don’t know why that is? Others can develop Type 2 Diabetes but Doctors don’t warn you about this! Of course, in an emergency situation, where your life is at stake it is a doctors decision to take out your Gall Bladder. My suggestion is don’t wait for the next attack. Take Soy Lecithin 1360mg. It work by thinning the bile in the body. thick bile in the body causes stones to form in the Gall Bladder and also causes them to move and block the ducts causing a Gall Bladder Attack.. It is no wonder that thinning the bile will prevent more stones from forming. Taking Soy Lecithin does not get rid of the stones you already have, unfortunately. Since healthy thin bile helps other organs in the body function at optimum levels it means you may feel a greater sense of wellbeing as organs are functioning better. I wish you improved health!

  4. OK, I’ll decide. With the wrongful deaths of the medical industry at 100,000 a year in the U.S. alone… well, I could go on, but your silence on that *FACT* sends sirens wailing about your lack of credibility(!) and the compounding factors in the medical industry’s DECEIT makes the other factors superfluous.

    Suffice it to say, trusting doctors is like trusting the government or trusting the mob. I’ll search the facts out myself and put the medical industry AT THE VERY BOTTOM of the list in CREDIBILITY.

  5. Many years ago a dear friend of mine noticed that her Mom was having memory problems. She would repeat herself and ask the same questions over and over. My friend put her Mom on 3 Triple lecithin (1200 mg) capsules with each meal. Within 2 weeks she no longer had issues with her memory.
    As an aside, I have studied in the field of functional nutrition/supplementation for over 40 years. Lecithin is a potent fat emulsifier, much more likely to positively impact the heart. There is too much to the process to go into here, but one thing the heart depends on to function normally is free fatty acids. Lecithin can help liberate these so that they can be used by the cells for fuel rather than stored as fat either in the organs or blood vessel system.

  6. My lifestyle is not too healthy, for nine years my wellman checkups showed my bad cholesterol as borderline high. Pretty stable set of results I’d say. A friend recommended Lecithin some time in 2013. I take two large softgels in the morning, each contain 1360mg of soya lecithin, according to the bottle. My last wellman checkup showed my cholesterol at a very healthy level. My doctor who sails and is skinny as a rake told me it is actually lower than hers, she was astonished. Nothing else in my diet or lifestyle has changed. That’s the only case study I need for now. I’ve been waiting for my next wellman to see if this is continued (in fact I just realized I should have had it this month).

  7. And adrenalin turns up in those who are scared -it gets you out of trouble. Surely a high amount in the gut is trying to counteract the heart attack bt too little too late

  8. Thanks for the interesting comments. Jay’s comment actually makes a lot of sense -lecithin is an emulsifier, and it could conceivably dissolve sludge or even a small size gallstone and thus relieve the symptoms. But so far, this is an experiment with N of 1 (sample of one). A proper trial would be very interesting. The other comments suffer from the same problem: they are testimonials that amount to N=1. None of them quoted a peer reviewed trial, the gold standard in clinical trials. Only such trials can demonstrate cause and effect.
    Gary Sellars comment is a bit over the top. To equate physicians to the mob is insulting. Yes, there are bad actors among physicians, just like in society at large. But there are thousands who put their lives at risk treating awful epidemics such as ebola, or the sick and injured in combat zones.

    • It’s difficult to decide whether to play it safe in light of the information you provided, or take a chance and move forward with the highest quality soy lecithin from a reputable lab. As a middle-aged man who is managing his diabetes, and given a choice of playing it safe or giving something a try based on anecdotal information from personal experiences, I tend to be risk adverse and play it safe.

      However, I’m asking after reading your article, were those with a correlation of lecithin metabolites with heart attacks and strokes, consumers of lecithin supplements? If not, then are the results an argument to avoid all foods containing lecithin, and if so, does that mean cutting out nutritious foods with benefits that may offset their lecithin content? Not knowing if those suffering heart attacks and strokes, whose conditions correlated to the presence of lecithin metabolites, were (a) consumers of foods containing lecithin; (b) consumers of lecithin supplements; or (c) personally not metabolizing lecithin properly due to perhaps lecithin intolerance or allergies, well, these factors appear unknown (or you would have mentioned them). Thus, I feel that I’m making a health decision based on weighing risk factors, similarly to choosing a mix of investments for my life savings (which could make or break my retirement). Just like I don’t dare just sit on my retirement money, too fearful of any risk, I must make a decision on choosing the highest quality supplements to physical survive retirement with hopefully a decent quality of life.

      I feel moved to try soy lecithin because in spite of eating a pristine, low-fat diet without sugar, and getting a reasonable amount of activity, my recent diabetic retinopathy showed, for the first time, slight evidence of retinopathy. I’m not getting any younger, I’m faithfully taking 1,000 mg of Metformin in the morning and again at night, and I’m trying to move rationally (but not panicked) to supplementation such as soy lecithin, salmon oil from wild sources, vitamins from reputable labs (vs. the drugstore variety), lots of organic salads with organic whole rye, lots of water, no meat (except wild fish on occasion), and keeping my fingers crossed.

      • Don’t use commercial/generic soy lecithin, if you think/decide a soy lecithin-based product is what you want then go for non-gmo organic soy product manufactured by a reputable health supplement company (Canadians or Europeans are best since they are regulated by third party agencies for purity, quality control/good manufacturing practices invested in their products).
        Personally i’m not a fan of any kind of soy product, I suggest you try sunflower lecithin.
        My humble recommendation comes from my last 10 yrs experience as a certified fitness trainer/nutritionist with emphasis towards sport medicine.
        I see that you are following an specific regime of food intake and exercise, that’s great regardless of your condition, the extend of the benefits you’ll get is definitely worth the effort.
        My advise, try a moderate fat intake rather than low, choose supplemental fats like fish oil and coconut oil (2 teaspoons a day and grill your food with it, just a dab) for dietary consumption.
        Make all your carbs be complex carbs from cruciferous vegetables, vegetables high on bioflavonoids/carotenoids (do not boil them but steam them, buy them whole and fresh nothing canned) and oatmeal only.
        Also buy supplemental nutritional fiber ( and I don’t mean Metamucil) for this you need to visit a real health food store.
        Eat lots of clean protein such as skinless chicken or turkey breast, wild caught fish never farm-raised (Tilapia has natural low levels of mercury) get a chart that indicates fish with lowest level of mercury, and last but not least get a good clean whey isolate powder product, use it in between your solid food meals 1 serving (30g) in the morning and another after your workouts, also as you said drink lots of water (squeeze a couple of good size lemons in every gallon of water).
        Your total daily caloric intake must be based on the weight target you want to achieve, make sure your physical training or “reasonable amount of activity” provides the necessary caloric deficit on a day to day basis. Divide your total daily caloric intake into 5 to 6 meals a day, am guessing you should at least be around 2200 cal. no less perhaps more, remember that extreme calorie-restricted diets don’t work ( 1200-1600 cal.)
        This eating plan will raise your metabolism (BMR) and will promote an overall healthy Ph (7.0 – 7.5) chemistry level in you body.

    • Dov,
      You are completely whacked. Not everything by its nature can be studied in the way you desire. If you disagree check out what Dr. Rhonda Patrick says. She works with Dr. Bruce Ames (Ames Test). If Doctors are not evil than the guards watching over the trains of Jews in WWII where not evil either. LOL

      Look at chemo therapy. The medical industry takes in hundreds of billion and it fails 96% of the time. No other industry survives with that kind of failure rate! People think of MD’s like Gods. At best, they are involved with disease management. I want cures not chronic management that lines the pockets of Big Pharma and MD’s.

      Doctors don’t even eat their own journals which makes things work. Yes, they are busy but so are day labors working the fields. Big Veg. don’t have the money to invest in double blind studies. Big Pharma won’t publish studies that go against their share holders.

  9. Supplementing with soy lectithins has helped a lot with my recent symptoms of irregular heart beats, shortness of breath, and constant discomfort in my chest. I was on a very healthy diet before these symptoms, as well as participating in vigorous exercise. I went to many doctors and cardiologists and a lady recommended lecithins so I decided to try it. I was going through symptoms everyday for 4 months but once I started supplementing, it probably only took 1-2 weeks to notice relief from this horrible experience. I’m looking forward to getting back to my regular self again. But I truly believe this has benefited my health. I literally had to put my life on hold for months, and had made too many expensive visits to specialists,ER’s ,and even Hopkins (which was going nowhere).

  10. Folks this says DOV. NOT DR. Lady you are full of crap. I take this stuff daily. If I miss a week because of vacation, I notice it. My Blood pressure has gone down, I think clearer. So stuff it. I bet you also believe the FAD. I didn’t know just anyone could post crap on the Internet and call it the truth… Do your research…better yet. Just shut up.

    • True, it says “Dov”, bur following the last name it says MD, PhD.

      HOWEVER, I take nonGMO lecithin granules, and have taken it as pure oil and capsuled oil. When I take the oil form 1TBSP, i have an incredible amount of energy! In fact, I made the mistake of taking it in the evening and was bustling around till the wee hours of the morning! That happened to my mom, as well. We learned to take it in the morning!

      Whether or not it has a negative impact in the lives of others, I don’t know. All a person can do is say what works for them.

      I decided and it will remain a part of my healthy lifestyle choices.

  11. Doc, there is no evidence that you accept because there is no money in studying it using the ultra-expensive studies that you will accept. Open your eyes.

    • If you read carefully this Brazilian study you find out that the study was conducted with 30 subjects, woefully inadequate sample size for drawing any statistical inferences. Furthermore, they were “selected”, not randomly assigned. Thirty out of how many? What were the selection criteria? We are not told.
      I am not impugning the authors’ intentions, only their experimental procedures. As to the substance, they claim a significant reduction in LDL cholesterol. The paper I am quoting in the post does not claim causation, only association, with TMAO, a lecithin metabolite that is associated with heart disease. Is LDL the sole culprit in heart disease? Definitely not. With all the research going into cardiovascular disease, we still don’t know more than we do.

      • Lethicin was a god sent for my son. He has tourette syndrome and as long as he takes lecithin capsules in a maximum form, by that I mean all at once. The dose increases as body weight goes up. In grade 4 he took 9 capsules of 1200mg capsules and like I said as his age and weight went up so did the number of capsules. It did without doubt took away his symptoms like the swearing and the involuntary muscle movements and the jerking and his concentration was much better. After this worked for my son, I wanted to shout it from the roof top but a lot of people are not open minded when it comes to natural health remodies. I encourage anyone who knows someone suffering with tourette syndrome to pass this on. When I questioned the doctor about this, he said he could not percribe this but what it did was block the dopamine going to the brain and tourette syndrome is too much dopamine going to the brain. I don’t know how accurate that is but what I do know is it works to take away or reduce symptoms of tourette syndrome.

  12. Incredibly unscientific, this claim. Since lecithin is in everyone and not just provided by supplements, we need to know if people suffering from heart conditions have faulty lecithin metabolism. Secondly, we need to know if those who have been found with elevated levels of these metabolites were, in fact, on lecithin supplements. Since these supplements are less commonly taken than they were in the past, my guess is that most of them probably were not.

  13. In the erstwhile, you’re going to prescribe your patients medicines with clinical evidence of causing heart attacks, like Meloxicam. Right, Doc?

  14. One thing I do have to tell you is that since I started Lecithin, my orgasms are a lot stronger I believe because of the larger load of semen released. Not trying to be funny or anything, this product works.. At least when it comes to that.

  15. I doubt lecithin is a cure-all for all of life’s problems, and I know that most supplement manufacturers are a bit crooked — but yikes! What a scare tactic here.

    I bet water is found in large concentrations within the bodies of heart attack and stroke victims. Let’s petition the government to ban that awful awful dihydrogen monoxide.

    • In fact, water is not found in abnormal concentrations in heart attack and stroke victims. The study I cited did not make any any recommendations, pro or con. It just presented the facts. It is up to every individual to weigh the evidence, consider the pros and cons, and makes his or her mind.

      • There were a lot of facts missing. Many extraneous variables can effect the rsults of a study. Questions I, as a researcher, would ask are:
        How and why were these particular subject’s blood chosen for the study?
        Were the patients on lecithin supplementation?
        Did the patients have any gastro-intestinal diseases such as ulcer (helico bacter pylori)IBS, Chron’s, colon cancer, pancreatitis, or other digestive disorder?
        What was the age of the patients in the study?
        What was the severity of the heart attacks?
        What co-morbid disorders did these patients have?
        And there are many more that could be asked. And researchers know that to show cause and effect, human studies would have to be conducted and following your logic on the danger of lecithin, this would be entirely unethical.

        Complete knowledge about the study sample and a second study that shows a repeat of these results are all needed before a fully informed decision can be made. Studies must be replicated to rule out faulty data collection and other possible problems with just one study. I did not see a like to a peer-reviewed journal article with this study, a must if I am to make a fully informed decision.

  16. I have made a commitment to try lecithin for a whole year with 2 or 3 heaping tablespoons a day. I started on Halloween day. Already i’ve noticed a difference in my mood and complexion. Will also see in a later date if my ldl cholesterol comes down or not.

  17. I read a rebuttal to the paper in Nature that stated though Lecithin metabolism does in fact generate “some” TMAO (which the body apparently eliminates quite swiftly), most all forms of seafood have been shown to cause remarkably higher spikes of blood TMAO. The implication being, if lecithin is bad, most any/all forms of seafood would be dreadful. No more seafood for you!

    Choline has also recently been reclassified as an essential nutrient and one of the earliest symptoms of choline deficiency is the development of fatty liver. Eliminate dietary (or supplemental if your diet is deficient) choline at your peril. It may produce trivial amounts of TMAO, but it’s not an optional nutrient if you wish to enjoy good health!

  18. The apparently slightly negative general impression you convey about Lecithin seems to relate to the fact that some of it must comprise “fatty acids”.

    As we know not all “fatty acids” are bad. I would even argue that oxidants (as differing from antioxidants) are needed by the immune system (for example)!

    The formulaeic concepts, often espoused by medical professionals – this good, that bad – must surely be considered simplistic at the very least.

    The presence of metabolites of Phosphatidyl Choline in people with heart disease etc. might well indicate that the body is utilising the PC to combat damage or disease in them. Precisely because they are under attack from these diseases.

    There is no logical correlation (so far shown) that shows whether PC (and therefore Lecithin) is helpful or harmful.

    Your article seems to underline the dilemma that conservative medicine finds itself in. Doctors, , I believe, on the whole, “weigh in” against alternative experiential “evidence” and reject self-treating and benign self-experimentation by their patients. To not consider widespread “unscientific” testimony is possibly one of the biggest mistakes our “modern” medical professionals and the pharmaceutical industry make.

    • Frank, you are absolutely right that correlations don’t make causation, and the study I cited falls into this category. Having said that, I think that it was appropriate, even incumbent upon us, to report on the study and leave the decision to the reader. In a more general vein, you really don’t know that what you are taking contains the amount of lecithin that is on the label, or that there is any lecithin at all in the bottle. Study after study carried out by reputable investigators and laboratories (not industry) showed that depending on the supplement between 20-80% of the samples were outright fraudulent. The problem doesn’t lie with the drug industry, or the “medical establishment”. Rather, it is our corrupt congress that received billions of dollars from the supplement industry and passed a law that prohibit the FDA from requiring the supplements industry from documenting safety and efficacy. Wouldn’t you want to know that the lecithin you think you are taking is actually there? that it is in the amount stated on the label? that it is safe? that its claims of efficacy are true? Ignorance is not bliss, and the vociferous defense of the supplements industry by people conned into blindly trusting their claims plays into the hands of a corrupt congress and corrupting industry money. If you want to see a damning account of supplements watch the latest PBS Frontline. Investigative journalism at its best.

      • I’m sure there is truth to there not be consistent standards in some supplements. However, there ARE pharmaceutical grade supplements which ensure you are getting what it says on the label and what you are paying for, and I have no qualms about using Lewis Labs Lecithin. To be fair, properly prescribed and properly taken drugs are somewhere around the top 4th leading cause of death. But those lobbyists have lots of money to throw around…funny you should mention how the news will attack supplements but where is that same concern over drugs and vaccines that are injuring and killing people? And now law has been passed to protect them but not their victims! Grrrr. As I say, the pharmacomafia has deep pockets, they should from their obscene profits, and it still isn’t enough for them because if they had their way they would shut down natural remedies in a heart beat. They’ve tried.

        As someone who worked in the hotel industry for many years, I witnessed first hand how the pharma companies would wine and dine, and pay for rounds of golf and spa treatments for the docs and their wives and send all their young and physically attractive reps to these conferences. So yes, while I want to make sure I’m getting the supplements I’m paying for, I also would like to see the pharma companies held just as accountable. And have them stop fudging their trials and getting their drugs out despite the serious risks of their drugs. And it takes a lot of deaths and drug injuries to get that drug pulled. By then they’ve made money hand over fist, and they are happy to settle out of court.

        Doctors these days are sadly not so much about really practicing medicine as it used to be, but writing prescriptions for drugs. But that never stops them from being haughty over natural supplements and medicine. Western medicine has it’s place, and I’m glad it’s there for emergencies…but other than that they can stay out of my business.
        They’ve attacked vitamin C for crying out loud, and we know how very effective that can be especially in mega doses and in IV form. So their self serving hypocrisy doesn’t give them much credibility in those who are awake and want to guide their own health care. And on that note…journalism is also very suspect these days, they are all bought and paid for and report just what they want people to believe. There is a definite agenda!

        • Thanks for your contribution, I agree with all your points. I am so glad I scrolled down after reading the doctors comments. I am just beginning with lecithin but I put credibility for those who have taken it for a while and see results. The doctor doesn’t.

      • DOV Michaeli,
        “The problem doesn’t lie with the drug industry or the “medical establishment”.” That has to be one of the most outrageous statements I’ve heard. The medical industry, e.g., schools, journals, individuals, was bought out decades ago by big pharma. The supplement industry had to lobby the government to avoid a take-over by big pharma and the medical community for a good reason. If you think for one instant big pharma and the medical establishment are scrutinizing research and looking after people’s health you are seriously living in a bubble. The current medical community has had more to do with skyrocketing illness post-WWII than any other entity. Are we supposed to trust the government and medicine to look after our health? The lipid hypothesis and the pathology and treatment of diabetes are just two of many examples of why not to have trust. And as far as monitoring supplements for safety, I’ll take the supplement industry over the drug and medical industries, and government any day. Antidepressants, cholesterol lowering drugs, vaccines, and on and on, make a health practitioner like myself, sick. And I haven’t even mentioned the food and edible oil industries that have also bought the medical establishment.

  19. Approach of your article too negative and i used lecithin for many years…..it certainly increase your semen quantity…….and protect your fat consumption after a heavy fat meal of beef…i am heart patient i can only eat beef if i add little lecithin after meal………..

    • As I said in many of my posts and reply to comments, association does not causation make. Having said that, when I see claims that something, lecithin or otherwise, can protect your heart from animal fat, make your thinking clear, increase your semen count, to name a few of those miraculous effects, my index of suspicion rises significantly. So I check the legitimate literature, and behold: other than claims and testimonials there is absolutely nothing to substantiate the claims. Now, unlike the true believers, I don’t have the certitude on the matter that they have. So I am looking for evidence, and I until it comes -I have grave doubts.
      In term of your specific case of consuming animal fat with the hope that lecithin will neutralize its effect, I suggest you consult your cardiologist.

  20. naturally like yur web-site but yyou need to check the spelling on quite
    a few of your posts. A number of them are rife with spelling issues and I to fjnd it
    verfy bothersome to inform the truth howqever I’ll certainly cokme agsin again.

    • Hello Jacinto,

      Thank you for coming to our site and reading our posts. We appreciate any feedback you have for us. So, really, thank you for informing us that there are a few posts that need to be fixed. Do you by chance know of which ones you read that needed to have the spelling corrected? We have over 4000 posts so it would be helpful to know which ones need to be fixed. We hope to hear back from you soon!

      Best,
      The TDWI Team

      • No post needs to be fixed. We come to these places sick, tired, and between family needs (dinners cooked) and work breaks for knowledge and to support our thoughts. So we type fast, especially when we are older, and don’t have time always to see that the index finger hit an “s” instead of the “a”. And some of us, well, we can’t spell great. When we get an idea, we think fast and type fast. To go check words every other line is like wathing an eagle follow the river when we are up to bat. It wipes out original thoughts.

  21. it is interesting to hear the different comments, my experience with lecithin has for the most part and as far as I can tell been very positive, I started taking about 2 months ago and I have noticed a definite improvement in my memory, so I will continue to take it and also recommend it to my friends.

  22. I blog quite often and I seriously appreciate your information. This article has truly peaked my interest.
    I’m going to book mark your blog and keep checking for new information about once per week.
    I opted in for your Feed as well.

  23. Lecithin, aka egg yolk, constitutes multiple phospholipids, all necessary for good health. So, we know, there is a definite need for these lipids, if one wants to remain healthy. We know a myriad of side effects, which, result from deficiency.
    By this point, I hope the Doc has kept up with research that fats; saturated especially, have been falsely demonized. They are essential and healthy.
    Regarding studies; the same criticisms you assault the supplement industry with, can be applied to pharma lobbyists, and the FDA. No different. Anyone can design a study, to give you the results you want, and diminish the bad. Which, is why we end up with drugs like Vioxx.
    Dr’s have practically zero understanding of the importance of food and it’s overwhelming impact on good health outcomes. There’s no money in nutrition for Pharma, or Dr’s. When your income is based on volume, things won’t change under our current system. Put all Doc’s on salary, give them proper nutritional training, educate the public on diet, and watch things change. That’s the way we bring costs down, extend life, and enjoy the fruits of a healthy society; one living up to its potential as a whole.

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  25. Just a question – it has been rumored to increase the amount of ejaculation in older men. Any truth to that?

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  26. When taken at night it helps you to relax and prevent the
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  27. Hi! Congratulations for your blog, and for your work. I have a auto-immune disease, so i´m special sensitive for the things i eat and/or suplement. And something very unusual happens to me after suplemented with lecithin. i was with my mestruation and after i take the lecithin like 3/4 hours, just stop completely. After that, and becouse with time i learn how to interpretate my body, i suspect that maybe this is not so good after all. I fund your blog after this becouse my intuition tells me thats something not right. I will continuo my research about this, and thanks for your information and apreciation on the topic becouse it was really a good starting point.

  28. Thanks for all the info! I have some autoimmune conditions, celiac, hashimoto, and reactive hypoglycemia all of which make me feel like I’m on a roller coaster. I also have trouble with soy, my question is do the non-soy products work just as well?

  29. That you spent your time writing about this weak research on the so-called dark side of lecithin rather than taking aim at poisonous pharmaceuticals shows your extraordinary bias. It would’ve been nice to see some scientific objectivity. Really, impugning lecithin! How can you defend this travesty in light of all the documented horrors of big pharma’s drugs, regularly dispensed.

  30. Magnificent web site. Plenty of useful information here.
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  31. What if the metabolites of lecithin were in the blood stream after a heart attack or stroke to help heal the damage?
    Interesting how the doc jumped to the other conclusion.

  32. I had my cholesterol level tested 2 yrs ago and it came back as 6.5. my GP said I was have to get it down and we would try diet first before going on statins. I was worried because I am very active and have a good diet of natural foods don’t like fatty foods. A friend recommended Lecithin as her husband had used it. I bought the granuals and sprinkled them over my muesli and soup and potatoes. Went back 4 weeks later and cholesterol was 5.2.. my GP was amazed it had come down so much so quickly. I was pleased with myself, so thought That’s all I need to do..Recently I had another blood test and it is up to 6.7! So I have started Lecithin again, this time I am not going to stop.

  33. I have been searching for lecithin info, as I take quite a bit for my recurring mastitis. I have gained weight! UGH.

  34. It’s actually very complex in this active life to listen news on Television,
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  35. Thank you a lot for sharing this with all of us you really understand what you are talking about!
    Bookmarked.

  36. I have started taking lecithin because I have been breastfeeding for about two years and suddenly I was getting clogged ducts at least once or twice a week. HORRIBLY PAINFUL!! A friend suggested this and after one day of a double dose and a day of just a regular dose, the clog was gone. I take 1 capsule (1200 mg) daily and have not had a clog since.

    I can’t see how this stuff is so bad for you???

  37. That is very flimsy evidence.
    Lecithin in the blood could be a result of the body not metabolising it into acetylcholine properly which controls muscle contraction.

  38. I had a stroke 5 years ago it left me unable to talk and I could not use my right hand. I am better now I can say words slowly. I was taking soy lecithin regularly I don’t remember why.

  39. I believe that there is truth that Soy Lecithin can bring on Heart Attacks and Strokes. I have a heart condition called SVT and whenever I eat any foods that have Soy Lecithin, my heartrate increases. It hasn’t brought on an attack yet but I try to stay away from any foods with Lecithin in it. That also goes for many other different kinds of food additives and preservatives. My cardiologist says I have possibly developed food sensitivities. Almost all of my SVT attacks have been brought on by a food that I have eaten that has additives in it. A diet as natural as possible is the best for all of us. I also don’t believe anymore in taking any supplements…they’re loaded with all kinds of preservatives and chemicals that aren’t good for us. Also, a suggestion, if I may for the gal who gives her son Soy Lecithin for his Tourette’s….I too struggled with my son for many years trying to get a handle on his tics and other Tourette behaviors, I know it’s hard….in the end, it was keeping him physically active and I mean really active that helped him most with calming down his tics. It gets better as they get older so just hang in there! Very Interesting article.

  40. I did this with my personal cell phone, which ‘ unlike my work Blackberry ‘ had
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  41. […] But don’t just randomly pick lecithin off the supplement shelf.  And if you see “soy lecithin” in the ingredients of processed food, that is not what you want.  There is a big difference between lecithin and soy lecithin as mentioned in thruthnhealth.com   Also read article on bodyecology.com and thedoctorweightsin.com […]

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  45. Comment:it is so sad to see how pharmaceutical drugs destroys many lifes everyday but medical professionals keep on recommending such poison.

    I nearly died in hands of medical professionals prescription of their synthetic drugs and hormones . but since I started my regime of lecithin and iodine I am free from migraine, irregular heartbeat, irregular periods and I am looking forward to a healthy natural life.

    Dr on this conversation is a real hypocrite . but I am not surprised because medicine professionals vowed hypocratic oath .

  46. Im 25 and I’ve just started taking lecithin to help with my blood pressure as Im looking into getting back into professional sports after a many year lay off. I first heard about lecithin when I was a door to door salesperson and I chanced upon a 90 something year old man with a large gut but spoke and acted as healthy as ever. For some reason we got to talking about health and he kept telling me about the benefits of Lecithin and convinced me to research and try it out. The book he showed me was some encyclopedia of health from the 1950s or some similar era. But seeing the health of this man in his mid 90s living alone in his own home and boasting about lecithin non-stop has convinced me that its worth looking into. Something to note might be that the lecithin of his day was probably more natural and maybe derived from egg yolk but I don’t know for sure.

  47. Lecithin did not work for me. I developed heart palpitations when I began using it. I’m glad I came across this article because it confirmed for me what I was experiencing. If lecithin works for you, fine, keep using it. But there are no miracle supplements that work for 100 percent of the people 100 percent of the time.

  48. One interesting point is that lecithin is an emulsifier agent so when taken with a powerful anti-oxidant like delta tocotrienol, it enhances the anti-cancer properties… google the terms “tocotrienol apoptosis” and you will find countless studies on the cancer killing benefits.

  49. I don’t normally comment on these forums but I must say I bought lecithin in hopes that it would help with a fatty liver. I don’t know how well it will work for that because I’ve only taken it for two days but after the first night I woke up feeling noticeably less pain from my fibromyalgia and from the first time I took it, i had one of the most restful sleeps I’ve had in a long time as I also suffer from insomnia. I said to my mom wonder if it’s my imagination but I contined feeling better after day 2 of taking it. I’d say it’s worth a try. I use sunflower lecithin though as I find I get stomach issues when I take soy products.

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  51. Excellent website. Plenty of useful info here. I’m sending it to a few buddies ans also sharing in delicious.
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  52. So is non gmo soy lecithin better than sunflower lecithin ? NOW brands, Lewis Labs, Life Extension?? Any recommendations?

  53. Shame shame mr. Doctor… Perhaps get your ignorant head out of your ass and actually DO some research. If you did, instead of spreading false propaganda and using your “degree” in an advantageous way to try and fool those that think a doctors words and opinions are like god, then you’d realize that there is plenty of research that backs up many claims associated with lecithin and choline intake. And my god, anyone still stuck on the notion that fat is what makes people fat, needs to open their eyes and inform yourself. There’d indigenous tribes out there in the world with diets that boast saturated fat percentages of %70 +. I can’t believe it’s 2017 and we still have clowns like this writing bullshit articles, resting on some phony piece of paper… Oh I mean degree sir lord majesty. Please enlighten me with more of your bullshit

  54. I found this article when googling “does lecithin improve cognition”. I started using this daily in vegan baking and noticed within a few months, that I was much sharper and was had clearer thinking. It really works for me.

    • One of my work mate’s step dad took a tablespoon of lecithin every day and credits that for staying mentally sharp until his death at age 98.

  55. Through it all, I believe that everyone is different. We all have different reactions. I was on 80 of Lisinopril (it only comes in doses of 40) baby aspirin and Amlodopine for HBP. Pressure was at 150+/90 sometimes 102. I started drinking 8oz of beet root juice mixed with/pineapple/carrot/parsley/1/2tbs fresh lemon juice with 1/2tsp or Ceylon cinnamon and raw honey. BP is 107/71 no meds. Doc took me off and had no idea about what I was using. Natural is always the best way. Those who believe, believe. Those that don’t, don’t. I’d rather pay for something that works naturally than to put my life in the hands of doctors, who are sometimes very good, but they only have a license to “PRACTICE”. I’ve gone back to Eden. Healthier, safer, and trustworthy. By the way I turned 65 in November and people think I’m 15 – 20yrs my junior. Do the research for yourselves and find something that works for you. It’s out there but you have to search.

    • HI Carolyn, I am glad to learn about your success managing your blood pressure naturally. We are big advocates of food and exercise as medicine. I think it important to point out that when it comes to supplements (pills and powders and other formulations of vitamins and other substances, despite being medicine, they are unregulated in the US. Also, we know that vitamins probably work differently – more effectively when ingested in the context of whole food, not pills. We hope you continue your healthy lifestyle and be well.

  56. For what it it worth, I am 67 years old and have been taking lecithin since I was a teenager (my father was into natural foods). For years I have taken a non-GMO lecithin product
    that I mix into my morning homemade yoghurt. I put in two heaping teaspoonfuls. This I eat religiously every day. My blood pressure today was 99 over 59 with a 57 pulse. This
    is normal for me. I gave up smoking six months ago and had smoked two packs a day for 50 years. I feel great. Despite the smoking I have hiked almost every day for 50 years.
    Lecithin gives me such a feeling of well-being that the few times I run out of it I can really tell the difference. I do recommend this highly and know in my heart it is good for the human body.

  57. This design is incredible! You certainly know how to keep a reader entertained.
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  58. Dov Michaeli,

    Thanks for your article. Do you have any ideas for why taking choline sources (Choline bitartrate or lecithin) causes me to suffer a great deal of anxiety? I’m generally aware that taking benadryl dulls me, which is attributed to the anticholinegeric effects, but it’s pretty much the only drug I’ve tried that actually helps for my allergies. I’ve tried pretty much every OTC drug out there.

    So basically, I’m trying to counter my benadryl usage by taking choline, and the choline is giving me extremely notable anxiety.

    • Ryan,
      Benadryl is an antihistamine which has what is called an anti-cholinergic activity. What that means is that it enhances the activity of neurons that have acetylcholine receptors on their membrane. Among other cholinergic effects is the drowsiness that it causes. Choline per se does not bind to the cholinergic receptor (despite the confusing terminology). It needs to first get converted to acetylcholine by a specific enzyme, which is located in the brain. But choline does not cross the blood-brain barrier at high concentrations, so you would not expect any effect on cholinergic neurons, including drowsiness. I don’t know why it should cause the anxiety you describe, since it cannot get to the brain in large quantities.

      • Dov Michaeli,

        http://www.sciencedirect.com/science/article/pii/0024320575901940 “Brain acetylcholine: Increase after systematic choline administration”

        “http://jpet.aspetjournals.org/content/220/2/322.short “Effects of phosphatidylcholine administration to rats on choline in blood and choline and acetylcholine in brain.”

        It appears to me it does cross the blood brain barrier on rats anyway? Although those two studies conflict on acetylcholine increase, that might be attributed to the different choline source?

        Also, have you seen this? http://ajcn.nutrition.org/content/90/4/1056.short “Choline in anxiety and depression: the Hordaland Health Study1,2,3”

        Which is funny. Increasing my plasma levels seems to do the opposite of what that study could imply. I’m aware that correlation != causation.

        • Choline crosses the small intestine, but only in limited quantities, because the pump that takes it through the gut wall has limited capacity.
          The excess choline in the diet is metabolized by the gut bacteria. It then reaches the blood circulation and is taken up by the body’s tissues, where it is constitutes part of the cell membrane. It can go through the blood brain barrier, but only in limited quantities. There it is used to replenish and re-build the cell’s membranes, just like in the rest of the tissues. Some of it is acetylated to make acetylcholine, a neurotransmitter.
          Of course you could increase the brain content of choline by iv injection, but this is not a physiological pathway: the pump that takes up the choline gets saturated at low concentration and the excess is getting into the brain by diffusion.
          But there is another aspect to the choline story. We are only partially dependent on dietary choline. The liver synthesizes most, or all, our requirements. This is why there there is no MRD for it.
          I am not aware of DMB in virgin oil.

          • “Getting into the brain by diffusion” Is crossing the blood bran barrier, isn’t it?

            I don’t know what MRD stands for, but I see that there is an average intake recommendation set https://ods.od.nih.gov/factsheets/Choline-HealthProfessional/

            It also appears that bad things happen when people don’t get enough of it:
            https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3601486/ “Choline Metabolism Provides Novel Insights into Non-alcoholic Fatty Liver Disease and its Progression”

            “Choline was once believed to be a dispensable nutrient because there is a pathway for endogenous formation of phosphatidylcholine catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). However, controlled clinical feeding studies demonstrated unequivocally that choline is an essential nutrient; humans deprived of choline developed either fatty liver and liver cell death or developed skeletal muscle damage”

            Of course AI for me is 550mg and I’m taking 2.5G through lecithin; none of that supports excessive dosages. I didn’t realize taking it through the gut wall was the bottleneck. I’ve been looking for a study on that, and haven’t found one thus far, but I’ll look later when I have the time.

          • MRD stand for Minimum Daily Requirement. The reason they don’t have one is that normally the liver synthesizes most of the requirement, and the rest comes from a normal diet. The source of the information of gut absorption of choline comes from J Pharmacobiodyn. 1987 Oct;10(10):571-9. What the paper shows is that the choline pump transports choline only if the tissue concentrations of choline is below 100 microM. In other words, If your liver makes choline at its normal rate, and if your diet is normal, than the uptake through the gut is limited.

      • Further, how does our brain get choline if it doesn’t cross the blood brain barrier? (I’m not pretending I know, or that the rat studies are conclusive.) I do know with painful acuity that choline bitartrate and lecithin affect my mental state. I just don’t know why. Maybe it’s a digestive issue?

        I like your articles, by the way. You’re a well reasoned man. You should do one on lithium orotate. :)

  59. so lecithin from vegan sources such as sunflower is healthy becuase it does not increase tmao wheras choline from animal souces does

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