Genia Technologies

Allison Ballmer, Director of International Business for Genia Technologies, a member of the Roche Family, joined Pat Salber (@docweighsin) at the 2015 Personalized Medicine World Conference in Mountain View, California. Here is a link to the video: https://www.youtube.com/watch?v=oovAV37aoaA

Genia-NanoTagGenia’s mission is to make genetic information universally available. They have created a platform that makes gene sequencing simpler, faster, more accurate, and lower cost. Instead of using optical detection that requires complex sample preparation, they use nanopore technology that allows single-molecule semiconductor-based DNA sequencing (if you are interested in a more in-depth explanation of how this works, you can find it HERE). Because Genia’s technology is electrical, utilizing “the same inexpensive semiconductors that are present in consumer electronic devices such as cell phones, computers, and handheld devices,” it is smaller and less expensive than sequencers utilizing optical detection.

 

Democratizing DNA sequencing

Allison says the smaller, more affordable sequencers will allow DNA sequencing to be decentralized. This will democratize sequencing and make it affordable for patients everywhere. She goes on to say,

“…the promise of personalized medicine is that you can really understand your genome in a personal way and your clinician will be able to provide actionable information to you. What we see is an evolution of DNA sequencing has primarily lived in research. It has provided a huge amount of information to translational researchers that is now moving into the clinic in oncology, in prenatal testing, and in some other key applications…What we hope with Genia is that our platform, that is really well suited for decentralization, will be able to take a much lower cost version, in a tabletop way, and be able to decentralize it to your local hospital.”

 

Clinical applications

DNA
Graphic from Wikimedia

The clinical applications of DNA sequencing are already being developed. For example, cell-free DNA is being looked at for prenatal testing. The hope is that we will be able to look at blood from the mother and find fetal cell-free DNA that will provide information that currently requires more invasive techniques, such as amniotic fluid sampling. When the same idea is applied to oncology, the idea is to screen a cancer patient’s blood for cell-free DNA of the cancer. According to Allison, this may one day become a substitute for biopsy to monitor therapeutic response and the changes in biology of a cancer over the life of a therapy. She said, a big focus for Genia, and for the whole industry, is “how can we use DNA and the information that NextGen sequencing provides in clinical samples, such as cell-free DNA that we can get from blood.”

When I asked how close the Genia technology is to being ready to be deployed to labs and clinics, Allison hedged, saying that the technology is in development, but now, as a part of the Roche family, they are being well resourced and provided with a lot of medical influence, “so we hope to be in the clinic somewhere between 2 and 10 years.” Genia was acquired by Roche in June 2014 and is being integrated into their existing Roche Sequencing Unit.

Let’s hope it is closer to 2 than 10.

19 COMMENTS

  1. You suggest we understand our DNA. Quite the contrary. Just because our genes suggest a certain programming, doesn’t mean we understand data about our genes at all. Correlations do not allow us predictive power with the exception of full gene or significant function deletions. Furthermore no one is challenging the accuracy or predictive value of these various methods. Does the public understand PCR technology? It amplifies DNA sequences but what does that mean? Given the sheer number of “clips” amplified what happens if the clipped info magnified is wrong? I’ll answer that, a stronger prediction of incorrect information, that’s what.

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  3. I would point out that there are already two bench-top sequencers ‘democratizing the market’ for next-generation sequencing, one offered by my employer Thermo Fisher Scientific is called Ion Torrent and uses semiconductor technology as a central part of the sequencing method, just in the more conventional manner.

    (To be specific, Genia is single-molecule sequencing while Ion Torrent is what is termed ensemble sequencing, requiring a template amplification intermediate step. Here’s a blog post about template preparation that I wrote up some time ago if interested: http://www.yuzuki.org/next-generation-sequencing-template-preparation/ )

    As far as being ‘deployed in labs and clinics’, it is exactly the spread of this research-use-only technology that has spurred both the FDA to start regulating the laboratory-developed test (here’s the latest request for comment document: http://www.regulations.gov/#!documentDetail;D=FDA-2011-D-0360-0001 ) as well as the development of FDA-cleared use – the Ion Torrent PGM Dx listed as a Class II medical device: http://news.thermofisher.com/press-release/life-technologies/thermo-fisher-scientific-announces-listing-ion-pgm-dx-system-us-fda-

    This genomics technology is already having a huge impact in just the past few years, and becoming faster and easier to use. Just my $0.02.

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